This paper, High burden and pervasive positive selection of somatic mutations in normal human skin is fascinating. It suggests that the mutational burden is much higher than we expected in skin cells due to UV exposure. In addition, subclones exist in the skin that are positively selected for oncogenes.
It also makes me want to stock up on sunscreen.
Citation
BibTeX citation:
@online{laderas2015,
author = {Laderas, Ted},
title = {Somatic {Mutations} in {Skin} {Paper}},
date = {2015-05-26},
url = {https://laderast.github.io/posts/2015-05-26-mutational-burden-in-skin/},
langid = {en}
}
For attribution, please cite this work as:
Laderas, Ted. 2015. “Somatic Mutations in Skin Paper.” May
26, 2015. https://laderast.github.io/posts/2015-05-26-mutational-burden-in-skin/.